2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
    Neuronal Signaling
  4. TRP Channel
  5. TRPM2 Isoform

TRPM2

TRPM2 is a Ca2+-permeable, non-selective cation channel activated by temperature, oxidative stress, and NAD+-related metabolites such as ADP-ribose[1]. Mechanistically, TRPM2 connects reactive oxygen species to Ca2+ influx, immune response, apoptosis, and core body temperature regulation[1]. In inflammatory models, TRPM2-mediated Ca2+ influx drives chemokine production in monocytes and aggravates neutrophil infiltration[2]. TRPM2 also links oxidative stress to NLRP3 inflammasome activation, and Trpm2−/− mice resist crystal- or liposome-induced IL-1β-mediated peritonitis[3]. In sensory physiology, TRPM2 is required for non-noxious warmth detection in mice, defining a heat-sensitive role distinct from cold- and menthol-activated TRPM8[4]. For experimental applications, 2-APB rapidly and reversibly inhibits ADP-ribose-, cADPR-, and heat-activated TRPM2, while ACA inhibits H2O2-induced TRPM2-mediated Ca2+ entry in β-cells[5][6].

TRPM2 Related Products (5):

Cat. No. Product Name Effect Purity
  • HY-149143
    JNJ-28583113
    		Inhibitor 98.82%
    JNJ-28583113 is an TRPM2 antagonist with brain permeability. JNJ-28583113 inhibits TRPM2 blocked phosphorylation of GSK3α and β subunits. JNJ-28583113 protects cells from oxidative stress induced cell death. JNJ-28583113 also suppresses cytokine release in response to pro-inflammatory stimuli in microglia.
  • HY-P5883
    TAT-M2NX
    		Inhibitor 99.55%
    TAT-M2NX (tatM2NX) is a selective inhibitor targeting human TRPM2 channels and exerts inhibitory effects on ischemic stroke. TAT-M2NX reduces H2O2-induced calcium influx via TRPM2 channels. After traumatic brain injury in mice, TAT-M2NX preserves hippocampal long-term potentiation, improves memory function, and reduces infarct volume after middle cerebral artery occlusion, but it shows no effect on female mice. TAT-M2NX can be used in studies related to traumatic brain injury and ischemic stroke.
  • HY-141713
    ZA10
    		Inhibitor
    ZA10 is a selective TRPM2 channel inhibitor, with an IC50 value of 8.1 μM. ZA10 can effectively suppress intracellular Ca2+ overload triggered by TRPM2 channel activation. ZA10 significantly reduce the mortality of SH-SY5Y cells induced by H2O2. ZA10 can be used for the study of ischemia-reperfusion injury, inflammation, or other neurodegenerative diseases.
  • HY-178393
    TRPM2-IN-2
    		Inhibitor
    TRPM2-IN-2 is a potent and selective TRPM2 inhibitor (IC50 = 0.66 μM) with minimal activity against TRPM8 and TRPV1 (IC50 >10 μM). TRPM2-IN-2 exhibits robust neuroprotective effects in both in vitro oxygen-glucose deprivation/reperfusion (OGD/R) model and in vivo transient middle cerebral artery occlusion (tMCAO) mouse model. TRPM2-IN-2 can be used for ischemic stroke research.
  • HY-181481
    2'-Deoxyadenosine-5'-O-diphosphoribose sodium
    		Agonist
    2'-Deoxyadenosine-5'-O-diphosphoribose sodium is a TRPM2 agonist. 2'-Deoxyadenosine-5'-O-diphosphoribose sodium enhances calcium-induced currents in inside-out patch-clamp experiments using HEK293 cells expressing human TRPM2. 2'-Deoxyadenosine-5'-O-diphosphoribose sodium is a substrate for Nucleoside Triphosphate Diphosphatase 9 (NUDT9).